Oghenekaro Etebo, Emmanuel Dennis and William Troost-Ekong all featured for Watford but the Hornets suffered their second league defeat of the season.
The three players all played from start to finish in the encounter, but Heung-Min Son’s strike three minutes before half time was all Spurs needed to earn the maximum points.
However, despite the defeat, the Super Eagles players still put in a brilliant shift. Etebo held his own in the middle of the park with a park accuracy of 94%, which include one key pass.
Meanwhile, Dennis, who started brightly with a goal and an assist on the opening day, worked tirelessly on and off the ball.
Ekong would be disappointed not to keep a clean sheet, but he was also good in the defence, making four clearances in the match.
Watford will get a chance to bounce back when they welcome Wolves to Vicarage Road after the two weeks international break.
Ekong and Etebo have been invited for Nigeria’s World Cup qualifier against Liberia but won’t get to play against Cape Verde due to the UK’s travel restrictions.
However, Dennis will stay at Watford as he was not included in Gernot Rohr’s squad.